Goals

We study and engineer host-associated bacteria and their specialized metabolites for in vivo therapeutic and agrochemical applications. We are particularly interested in

• discovering new bioactive natural products from host-associated bacteria
• elucidating unusual pathways for natural product biosynthesis
• unraveling the ecological role and mode of action of natural products
• microbiome engineering for the production of high-value natural products and other therapeutic applications

Our work is multidisciplinary, combining molecular microbiology, synthetic biology, structural biology, metabolomics, enzymology, bioinformatics, analytical chemistry and chemical synthesis.